Physical and Physicochemical Methods (not limited to)
Absorption spectrophotometry, infrared, ultraviolet and visible
Liquid, Gas and Thin-layer Chromatography
Mass Spectrometry
Potentiometric titration
Potentiometric determination of pH
Relative density
Refractive index
Optical rotation
Viscosity
Melting point
Loss on drying
Conductivity
Acid, Ester, Hydroxyl, Iodine, Peroxide and Saponification values;
Complexometric Titrations;
Water: semi-micro determination.
Pharmaceutical Technical Procedures (not limited to)
Disintegration
Solid, Semi-solid and transdermal Dissolution test
Uniformity of mass
Uniformity of content
Friability of uncoated tablets
Resistance of crushing
Sieve test
Apparent volume
Flowability
Test for extractable volume of parenteral preparations
Limit Tests
Ammonium, arsenic, calcium, chlorides, fluorides, magnesium, heavy metals, iron, phosphates, sulphates, sulphated ash, total ash, aluminium, free formaldehyde.
Stability Studies
LEF is equipped with environmentally controlled climatic chambers, in accordance with ICH guidelines, to perform stability studies for API and pharmaceutical products under accelerated, intermediate and long-term stability conditions (25ºC&60% RH • 30ºC & 65% RH • 40ºC & 75% RH), in order to set a shelf life and expiration date.
Storage at specific climatic conditions can be organized on request.